Specialized
council 042
Armenian society of biological psychiatry
Armenian association for molecular
and cellular biology and immunology
Eng Rus Arm
YSSch - 2017
"MOLECULAR AND CELLULAR BASES OF HOST-MICROBES INTERACTIONS-2017"

YOUNG SCIENTISTS' SCHOOL PROGRAM:


P R O G R A M

May 22 - 26, 2017


Day 1 - May 22, Monday

09:00-10:00

Registration of Participants

10:00-10:30

Opening Ceremony

10:30-11:30

The actin cytoskeleton - Prof. Diane Barber
How cells build different actin architectures
Actin assemblies and nucleators

11:30-12:00

Cofee break

12:00-13:00

How cells use different actin architectures
Pathogens hijack actin assemblies in host cells
Regulated actin assemblies in metazoans - Rho GTPases and nucleation promoting factors

13:00-14:00

Lunch

14:00-16:00

Paper discussion
View and download supporting materials: Paper1, Paper2
a. Review: Pollard, Actin and actin-binding proteins. Cold Spring Harb Perspect Biol. 2016.
b. Reed et al., Rickettsia actin-based motility occurs in distinct phases mediated by different actin nucleators. Curr Biol. 2014.

Day 2 - May 23, Tuesday

10:00-11:00

Immunopathology - Prof. Bana Jabri
Role of dysbiosis - an altered pathogenic microbiome - in immunopathology
How differences in microbiome can predispose individuals to autoimmunity and inflammatory bowel disease
How environmental factors can alter the microbiome

11:00-11:30

Coffee break

11:30-12:30

Role of viral infections
How viral infection can break intestinal immune homeostasis and promote disease
The relationship between microbiome and viruses in health and disease

12:30-13:30

Lunch

13:30-15:30

Paper discussion
View and download supporting materials: Paper1, Paper2, Paper3, Paper4, Doc5
Reviews:
a. Franzosa et al., Sequencing and beyond: integrating molecular ‘omics’ for microbial community profiling. Nat Rev Microbiol. 2015.
b. Pfeiffer & Virgin, Viral immunity. Transkingdom control of viral infection and immunity in the mammalian intestine. Science. 2016.
Primary papers:
a. Vatanen et al., Variations in microbiome LPS immunogenicity contributes to Autoimmunity in human. Cell. 2016.
b. Kuss et al., Intestinal microbiota promotes enteric virus replication and systemic pathogenesis. Science. 2011.

Day 3 - May 24, Wednesday

10:00-11:00

Cell invasion during C. elegans vulval development- a model for cancer cell metastasis – Prof. Alex Hajnal

11:00-11:30

Coffee break

11:30-12:30

Paper discussion
View and download supporting materials: Paper1, Paper2
a. Review: Hubbard and Greenstein, Introduction to the germ line. Wormbook 2005
b. Lopez et al., DAF-2 and ERK Couple Nutrient Availability to Meiotic Progression during Caenorhabditis elegans Oogenesis. Dev Cell. 2013.

12:30-13:30

Lunch

13:30-14:30

Discussion and meeting with IMB staff

Day 4 - May 25, Thursday

10:00-11:00

Approaches to understanding bacterial survival – Dr. Haig Alexander Eskandarian
Evading the host
Globally regulating host transcription
Hijacking intracellular organelles

11:00-11:30

Coffee break

11:30-12:30

Bacterial tolerance to stress: Responses to antibiotics and antimicrobial peptides.
Evolution of resistance
Screening for resistors
Persistence against antibiotics

12:30-13:30

Lunch

13:30-15:30

Paper discussion
View and download supporting materials: Paper1, Paper2
a. Balaban et al. Bacterial Persistence as a Phenotypic Switch. Science. 2004
b. Wakamoto et al. Dynamic Persistence of Antibiotic-Stressed Mycobacteria. Science. 2013

Day 5 - May 26, Friday

10:00-12:00

Open discussion with lecturers

12:00-13:00

Closing remarks