Research activities of the Laboratory of Regulation of Cellular Activity are concentrated upon investigation of dysfunctions in the lipid
modification and signal transduction mechanisms in human peripheral blood mononuclear cell plasma membranes in diverse types of leukemia and solid tumor.
Particularly, it was shown that alterations in the processes of cell plasma membrane lipids fatty acid content modification and diverse endogenous lipid
second messenger molecules rapid and reversible generation in the stimulated cells as well as in the activities of endogenous lipid modification enzyme
systems are common characteristics for all types of cancer studied. Regular dysfunctions elucidated in the above mentioned mechanisms can be used for
diverse cancers early detection and assessment as well as for discovery of novel modes for the personalized treatment of cancers.
Current research projects:
«Investigation of lipid modification and signal transduction mechanisms in the peripheral blood mononuclear cells in diverse forms of
Current research activities of the laboratory are concentrated upon investigation of:
- Changes in the peripheral blood mononuclear cells plasma membrane phospholipid content in diverse forms of solid tumors;
- Possible association of different phosphoinositide-specific phospholipase C isoenzymes gene polymorphisms with the breast cancer risk.
Tadevosyan Yu.V., Alexanyan K.A., Lazyan M.P., Torgomyan T.R., Akobyan G.V., Ghazaryan R.A., Lipids of peripheral blood mononuclear cells in breast and ovarian
cancers. // (2014), Lipidology - Science of XXI Century, (editor: Siniaev D.N.), RF, Alliance, pp.109-122.
Hakobyan G.V., Batikyan Т.B., Amirkhanyan E.S., Altman A., Tadevosyan Yu.V., Lipids of peripheral blood mononuclear cells in leukemia. // (2013),
Lipidology - Science of XXI Century, (editor: Siniaev D.N.), RF, Alliance, pp.17-26.
T.R. Torgomyan, M.P. Lazyan, G.V. Hakobyan, T.B. Batikyan, R.A. Ghazaryan, K.A. Alexanyan, H.M. Galstyan, Y.V. Tadevosyan, Alterations in the lipid modification
processes of peripheral blood mononuclear cells in malignancy. // (2013), Electronoc Journal of Natural Sciences, NAS RA, Iss. 2 (21), pp. 30-33.
T.R. Torgomyan, M.P. Lazyan, Davtyan H.H., Davtyan A.G., Batikyan T.B., R.A. Ghazaryan, K.A. Alexanyan, H.M. Galstyan, Y.V. Tadevosyan, Blood mononuclear cell lipids
fatty acid content modification in breast and ovarian cancers. // (2012), Biol. J. Arm., 2(64), сс 73-79
Batikyan T.B., Akobyan G.V., Lazyan M.P., Torgomyan T.R., Ghazaryan R.A., Amirkhanyan E.S., Tadevosyan Yu.V., Regularities of endogenous lipid metabolites
generation in phorbol 12-miristate 13-acetate – stimulated blood lymphocytes in leukemia. // (2011), Biomedical chemistry (Moscow), v. 57, no. 4, pp.
M.P. Lazyan, H.H. Davtyan, T.B. Batikyan, R.A. Kazaryan, K.A. Alexanyan, H.M. Galstyan, Yu.V. Tadevosyan, Disturbances in lipid second messengers generation by
stimulated blood lymphocytes in breast cancer. // (2011), Biopolymers and Cell, V. 27, No 5, pp. 387-390
Hakobyan G.V., Batikyan T.B., Kazaryan R.A., Amirkhanyan E.S., Tadevosyan Yu.V. Phospholipid-catabolizing enzyme activities in blood lymphocyte plasma membranes
in hematological malignancies. // (2010), Biol. J. Arm., LXII, (suppl. 1), pp. 36-40.
M.H. Melkonyan, G.V. Akobyan, A.Y. Tadevosyan, T.B. Batikyan, E.S. Amirkhanyan, A. Altman, Y.V. Tadevosyan, Acylation of lipids by arachidonic acid and lipid second
messengers in anti-CD3/CD28-costimulated lymphocytes at norm and in diverse forms of leukemia. // (2007), Med. Sci. Arm.Мед., N. 2, pp. 56-63.
Amnon Altman, Sandra Kaminski, Valere Busuttil, Nathalie Droin, Junru Hu, Yuri Tadevosyan, Robert A. Hipskind, Martin Villalba. Positive feedback regulation
of PLC γ1/Ca2+ signalling by PKCθ in restimulated T cells via Tec kinase-dependent pathway. // (2004), Eur. J. Immunol., v.34, pp.2001-2011.
Yu.V. Tadevosyan, Cooperative processes of lymphocyte membrane lipid modification in chronic lympholeukemia. // (2000), In: Armenia 2XXX, Hi-Tech Directory,
Tadevosyan Yu.V., Asatryan L.Y., Batikyan T.B., Karageuzyan K.G., Tadevosyan A.Y., Processes of phosphatidylcholine catabolism at the early steps of lymphocyte
mitogenic initiation of phosphoinositide cycle. // (1996), Biochemistry, (Moscow), V. 61, No. 8, pp. 1414-1421.
Yu.V. Tadevosyan , K.G. Karageuzian, T.B. Batikyan, Cooperation of phospholipase A2 and phosphoinositide-specific phosphodiesterase functioning at
phosphoinositide-cycle initiation in rat brain synaptosomes. // (1987), Reports of USSR Academy of Sciences (Moscow), 295, pp. 1254-1257
Tadevosyan Y., Galstyan H., Batikyan T., Lazyan M., Hakobyan G., Alexanyan K., “Mode for diagnostics and/or state value of cancer. // (2009),
Patent #AM2311, G01N 33/53.
Tadevosyan Y., Batikyan T., Tadevosyan A., Hakobyan G., Melkonyan M., Mode for diagnostics and/or state value of leukemia’s. // (2008),
Patent #AM2256, G01N 33/49.