Investigations in our research group are focused on uncovering the molecular mechanism underlying the pathological events leading
to human diseases due to impaired function of ion channels. A large number of human diseases are caused by the dysfunction of ion channels due to
mutations occurring inheritably or due to impaired interaction/ modulation of channel.
To understand the molecular mechanisms that lead to the dysfunction of channels, a fundamental knowledge about their structure, function and physiological
role they plays in particular cells is required.
Research in our laboratory is focused on understanding the structure-functional correlation and physiological role of voltage-gated Kv potassium channels.
We utilize basic molecular biological (site-directed mutagenesis, RT-PCR), immuneohistocemical and electrophysiological (two electrode voltage clamp,
Current research projects:
Investigation of macroscopic inactivation mechanism in voltage-gated KCNQ potassium channel.
Intrinsic properties of potassium channel pore and it role in voltage-dependent gating process.
Investigation of KCNQ1 potassium channel regulation by intracellular Ca2+ ions.
Physiological significance of KCNQ1 channel in insulin secretion process of pancreatic beta cell.
Vardanyan V, Pongs O. 2012. Coupling of Voltage-Sensors to the Channel Pore: A Comparative View. Front Pharmacol 3:145
Heidenreich M, Lechner SG, Vardanyan V, Wetzel C, Cremers CW, De Leenheer EM, Aranguez G, Moreno-Pelayo M. Jentsch T. Lewin R. 2012.
KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. Nat Neurosci 15:138-45.
Ma LJ, Ohmert I, Vardanyan V. 2011. Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis. Biophys J 100:885-94
Ader C, Schneider R, Hornig S, Velisetty P, Vardanyan V, Giller K, Ohmert I, Becker S, Pongs O, Baldus M. 2009. Coupling of activation
and inactivation gate in a K+-channel: potassium and ligand sensitivity. EMBO J 28:2825-34