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GROUP OF MOLECULAR NEUROLOGY
HEAD:
Group members:
General information:
Investigations in our research group are focused on uncovering the molecular mechanism underlying the pathological events leading
to human diseases due to impaired function of ion channels. A large number of human diseases are caused by the dysfunction of ion channels due to
mutations occurring inheritably or due to impaired interaction/ modulation of channel.
To understand the molecular mechanisms that lead to the dysfunction of channels, a fundamental knowledge about their structure, function and physiological
role they plays in particular cells is required.
Research in our laboratory is focused on understanding the structure-functional correlation and physiological role of voltage-gated Kv potassium channels.
We utilize basic molecular biological (site-directed mutagenesis, RT-PCR), immuneohistocemical and electrophysiological (two electrode voltage clamp,
patch-clamp) technique.
Current research projects:
Investigation of macroscopic inactivation mechanism in voltage-gated KCNQ potassium channel.
Intrinsic properties of potassium channel pore and it role in voltage-dependent gating process.
Investigation of KCNQ1 potassium channel regulation by intracellular Ca2+ ions.
Physiological significance of KCNQ1 channel in insulin secretion process of pancreatic beta cell.
Selected Publications:
>> Full publications list of IMB