Specialized
council 042
Armenian society of biological psychiatry
Armenian association for molecular
and cellular biology and immunology
Eng Rus Arm

GROUP OF CELL TECHNOLOGIES


HEAD:

Zhanna Ktsoyan, PhD

E-mail: zh_ktsoyan@mb.sci.am

Phone1: +374 99 460-071

Phone2: +374 10 231-499

Group members:

  1. Anahit Sedrakyan, PhD
  2. Alvard Hovhannisyan, PhD
  3. Mkhitar Mkrtchyan, PhD
  4. Karine Arakelova
  5. Magdalina Zakharyan

General information:

Field: Host-microbe interaction i.e. link between microbiota-metabolites-pathogen–inflammation.
Direction: Genotypic and phenotypic diversity of non typhoid Salmonella, defining the peculiarities of different inflammatory response and the outcome of disease.

Current research projects:

Development of molecular epidemiological map of Salmonella in Armenia for best prevention and intervention strategies.

Molecular genetic characterization of Salmonella strains circulating in Armenia to elaborate the most efficient salmonellosis prevention and treatment approaches.


Targeted elimination of multidrug-resistant (MDR) Salmonella by bacteriophages.

Identify and characterize the most clinically problematic highly virulent, persistent and drug-resistant strains of Salmonella that cause excessive morbidity and mortality in participating countries, Armenia, Georgia, and Tajikistan; as well as design phage therapy approaches for efficient control and elimination of these dangerous pathogens from agricultural systems, human food chain, hospitals, and the environment.

Selected Publications:

>> Full publications list of IMB
  1. Ktsoyan Zh., Mkrtchyan M., Zakharyan M., Mnatsakanyan A., Arakelova K., Gevorgyan Z., Sedrakyan A., Hovhannisyan A., Arakelyan A., Aminov R., Systemic concentrations of short chain fatty acids are elevated in salmonellosis and exacerbation of familial Mediterranean fever. // Frontiers in Microbiology, 2016, vol. 7
  2. Ktsoyan Zh., Mkrtchyan M., Zakharyan M., Mnatsakanyan A., Arakelova K., Gevorgyan Z., Ktsoyan L., Sedrakyan A., Hovhannisyan A., Ghazaryan K., Boyajyan A., Aminov R., Differential induction of total IgE by two Salmonella enterica serotypes. // Frontiers in Cellular and Infection Microbiology, 2015, vol. 5.
  3. Ktsoyan Zh., Beloborodova N., Sedrakyan A., Osipov G., Khachatryan Z., Manukyan G., Arakelova K., Hovhannisyan A., Arakelyan A., Ghazaryan K., Zakaryan M., Aminov R., Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome. // Frontiers in Cellular and Infection Microbiology, 2013, vol. 3
  4. Ktsoyan, Zh., Ghazaryan, K., Manukyan, G., Martirosyan, A., Mnatsakanyan, A., Arakelova, K., Aminov, R., Inflammatory Responses to Salmonella Infections Are Serotype-Specific. // International Journal of Bacteriology, 2013.
  5. Khachatryan Z, Ktsoyan Zh, Manukyan G, Kelly D, Ghazaryan K, Aminov R., Predominant Role of Host Genetics in Controlling the Composition of Gut Microbiota. // PLoS ONE. 2008, vol. 3, No. 8.