Specialized
council 042
Armenian society of biological psychiatry
Armenian association for molecular
and cellular biology and immunology
Eng Rus Arm

LABORATORY OF MICROBIAL GENOMICS


HEAD:

Anahit Sedrakyan, PhD

E-mail: a_sedrakyan@mb.sci.am

Phone1: +374 93 459-954

Phone2: +374 10 231-499

Group members:

  1. Alvard Hovhannisyan, PhD
  2. Karine Arakelova
  3. Magdalina Zakharyan
  4. Shoghik Hakobyan, PhD student

General information:

The research activities of the laboratory are focused on the most common foodborne bacterial pathogens circulating in Armenia for developing the appropriate strategies to control the most common foodborne diseases in Armenia. One of the research tasks of the laboratory is to study the potential of bacteriophages to control bacterial infections and spread of antimicrobial resistance.

Over the past two decades, due to the cooperation with the "Nork" clinical hospital of infectious diseases (MH, Armenia), the monitoring of antimicrobial resistance in clinical non-typhoidal Salmonella enterica isolates and the study of the immune status of patients with salmonellosis were carried out. In particular, we discovered that the profile of inflammatory responses during the Salmonella infection depend on the serotype of the pathogen. Our results suggest that nontyphoidal Salmonella infection contributes to the generation of autoantibodies and may play a role in autoimmune disease.

Within the frame of the ISTC Project A-2140 (2016-2019), WGS and annotation of 44 clinical non-typhoidal Salmonella enterica isolates from Armenia was carried out for the first time. Extensive data were obtained that characterize the genetic patterns resposible for virulence and antimicrobial resistance of these isolates.

Current research projects:

In-depth characterization of human isolates of the most common in Armenia bacterial enteric pathogens displaying multi-drug resistance phenotype to improve AM therapy approaches and trace the emergence and lineage of clinically problematic and/or epidemiologically successful clones of these pathogens in Armenia.


Isolation of bacteriophages showing activity against multidrug resistant isolates of bacterial pathogens circulating in Armenia.


Selected Publications:

>> Full publications list of IMB
  1. Sedrakyan AM, Ktsoyan ZA, Arakelova KA, Zakharyan MK, Hovhannisyan AI, Gevorgyan ZU, Mnatsakanyan AA, Kakabadze EG, Makalatia KB, Chanishvili NA, Pirnay J-P, Arakelyan AA and Aminov RI (2020) Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica. Frontiers in Microbiology. 11:592223. doi: 10.3389/fmicb.2020.59222
  2. Makalatia, K.; Kakabadze, E.; Wagemans, J.; Grdzelishvili, N.; Bakuradze, N.; Natroshvili, G.; Macharashvili, N.; Sedrakyan, A.; Arakelova, K.; Ktsoyan, Z.; Zakharyan, M.; Gevorgyan, Z.; Mnatsakanyan, A.; Tishkova, F.; Lood, C.; Vandenheuvel, D.; Lavigne, R.; Pirnay, J.-P.; De Vos, D.; Chanishvili, N.; Merabishvili, M. Characterization of Salmonella Isolates from Various Geographical Regions of the Caucasus and Their Susceptibility to Bacteriophages. Viruses 020, 12, 1418. https://doi.org/10.3390/v12121418.
  3. Zhanna Ktsoyan, Lyudmila Budaghyan, Marina Agababova, Armine Mnatsakanyan, Karine Arakelova, Zaruhi Gevorgyan, Anahit Sedrakyan, Alvard Hovhannisyan, Mkhitar Mkrtchyan, Magdalina Zakharyan, Arsen Arakelyan and Rustam Aminov "Potential Involvement of Salmonella Infection in Autoimmunity" Pathogens 2019, Volume 8, Issue 3, 96; doi:10.3390/pathogens8030096
  4. Kakabadze E., Makalatia K., Grdzelishvili N., Bakuradze N., Goderdzishvili M., Kusradze I., Phoba M.-F., Lunguya O., Lood C., Lavigne R., Jacobs J., Deborggraeve S., De Block T., Van Puyvelde S., Lee, D., Coffey A., Sedrakyan A., Soentjens P., De Vos D., Pirnay J.-P., Chanishvili N, Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo, "Viruses", v.10, N4, 2018, p.172; doi:10.3390/v10040172
  5. Ktsoyan Zh., Mkrtchyan M., Zakharyan M., Mnatsakanyan A., Arakelova K., Gevorgyan Z., Ktsoyan L., Sedrakyan A., Hovhannisyan A., Ghazaryan K., Boyajyan A., Aminov R., Differential induction of total IgE by two Salmonella enterica serotypes. // Frontiers in Cellular and Infection Microbiology, 2015, vol. 5; doi:10.3389/fcimb.2015.00043
  6. Ktsoyan Zh., Beloborodova N., Sedrakyan A., Osipov G., Khachatryan Z., Manukyan G., Arakelova K., Hovhannisyan A., Arakelyan A., Ghazaryan K., Zakaryan M., Aminov R., Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome. // Frontiers in Cellular and Infection Microbiology, 2013, vol. 3; doi:10.3389/fcimb.2013.00002