Complement lectin pathway regulators in human schizophrenia and ischemic stroke.
The overall objective of this project is to clarify the role of complement lectin pathway regulators, MASP-3,
MAp19 and MAp44 in pathogenesis of SCZ and IS by investigating the potential association of their most informative genetic variants and blood levels with these disorders.
Schiff base cyclic amino acid derivatives for chemoprotection against damaging action of mycotoxins.
The aim of the project is to evaluate a potential ability of Schiff base cyclic amino acid derivatives including
picolinyl-L-phenylalanine, picolinyl-L-tryptophan, nicotinyl-L-tryptophan to act against damaging effects of aflatoxin B1, ochratoxin A, and T2-toxin mycotoxins.
Study of synaptic plasticity regulating transcription factors in schizophrenia.
Alterations in synaptic plasticity (SP) are involved in schizophrenia pathogenesis. Molecular mechanisms of these
alterations are unclear. A number of transcription factors, including Ier5, c-Fos, c-Jun, and AP-1 (complex of c-Fos and c-Jun), regulates SP. Present project aims
to evaluate a functional state of mentioned transcription factors in schizophrenia. For this purpose, in schizophrenia patients and healthy subjects functional
polymorphisms of Ier5, c-fos, and c-Jun encoding genes will be studied, blood levels of Ier5, c-fos, and AP-1 proteins will be determined and phenotype-genotype
relationships will be assessed. The obtained results will elucidate molecular pathomechanisms of SP alterations in schizophrenia, enrich existing knowledge about
genetic factors of schizophrenia, create base for development of methods for correction of SP.
Searching for schizophrenia biomarkers among the genes of synaptic proteins.
The overall aim of this project was to clarify the role of the nerve growth factor (NGF) and its receptor (NGFR)
in the pathogenesis of SCZ by investigating the potential association of their most informative genetic variants and blood levels with this disorder.