Specialized
council 042
Armenian society of biological psychiatry
Armenian association for molecular
and cellular biology and immunology
Eng Rus Arm

LABORATORY OF HUMAN GENOMICS AND IMMUNOMICS


HEAD:

Arsen Arakelyan, PhD

E-mail: aarakelyan@sci.am

Phone: +374 10 282-061

FAX: +374 10 282-061

Laboratory members:

  1. Violeta Ayvazyan, PhD
  2. Gohar Mkrtchyan, PhD
  3. Karine Mayilyan, Dr.Sc
  4. Roksana Zakharyan, PhD
  5. Gohar Tsakanova, PhD
  6. Elina Arakelova, PhD
  7. Andranik Chavushyan, PhD
  8. Varduhi Hayrapetyan, PhD
  9. Gevorg Martirosyan, PhD
  10. Ani Stepanyan, PhD
  11. Hovsep Ghazaryan, PhD
  12. Diana Avetyan, PhD
  13. Ani Melkonyan
  14. Sofi Atshemyan
  15. Shushanik Antonyan

General information:

The research interests of the laboratory are focused on the study of genetic variability of genes involved in immune-neuroendocrine interactions in a number of polygenic complex human diseases including schizophrenia, posttraumatic stress disorder, ischemic stroke, myocardial infarction, diabetes, etc. The overall aim of these studies is the elucidation of molecular and cellular etiopathomechanisms of complex diseases, the identification of vital molecular biomarkers and therapeutic targets, and discovery of new physiologically active compounds of potential therapeutic significance.

Current research projects:

Complement lectin pathway regulators in human schizophrenia and ischemic stroke.

The overall objective of this project is to clarify the role of complement lectin pathway regulators, MASP-3, MAp19 and MAp44 in pathogenesis of SCZ and IS by investigating the potential association of their most informative genetic variants and blood levels with these disorders.


Schiff base cyclic amino acid derivatives for chemoprotection against damaging action of mycotoxins.

The aim of the project is to evaluate a potential ability of Schiff base cyclic amino acid derivatives including picolinyl-L-phenylalanine, picolinyl-L-tryptophan, nicotinyl-L-tryptophan to act against damaging effects of aflatoxin B1, ochratoxin A, and T2-toxin mycotoxins.


Study of synaptic plasticity regulating transcription factors in schizophrenia.

Alterations in synaptic plasticity (SP) are involved in schizophrenia pathogenesis. Molecular mechanisms of these alterations are unclear. A number of transcription factors, including Ier5, c-Fos, c-Jun, and AP-1 (complex of c-Fos and c-Jun), regulates SP. Present project aims to evaluate a functional state of mentioned transcription factors in schizophrenia. For this purpose, in schizophrenia patients and healthy subjects functional polymorphisms of Ier5, c-fos, and c-Jun encoding genes will be studied, blood levels of Ier5, c-fos, and AP-1 proteins will be determined and phenotype-genotype relationships will be assessed. The obtained results will elucidate molecular pathomechanisms of SP alterations in schizophrenia, enrich existing knowledge about genetic factors of schizophrenia, create base for development of methods for correction of SP.


Searching for schizophrenia biomarkers among the genes of synaptic proteins.

The overall aim of this project was to clarify the role of the nerve growth factor (NGF) and its receptor (NGFR) in the pathogenesis of SCZ by investigating the potential association of their most informative genetic variants and blood levels with this disorder.

Selected Publications:

>> Full publications list of IMB
  1. Avetyan D., Zakharyan R., Petrek M., Arakelyan A., Telomere shortening in blood leukocytes of patients with posttraumatic stress disorder, "Journal of psychiatric research", v. 111, 2019, pp. 83-88.
  2. Avetyan D., Arakelyan A., Mkrtchyan G., Association of Bax and Bcl-2 functional polymorphisms and protein levels with posttraumatic stress disorder, “Journal of Biosciences and Medicines”, v.6, 2018, pp.23-32.
  3. Stepanyan A., Zakharyan R., Simonyan A., Tsakanova G., Arakelyan A., Involvement of polymorphisms of the nerve growth factor and its receptor encoding genes in the etiopathogenesis of ischemic stroke, "BMC Medical Genetics", v.19, N33, 2018, pp.1-10.
  4. Tsakanova G., Stepanyan A., Nahapetyan K., Sim R., Arakelyan A., Boyajyan A, Serine proteases of the complement lectin pathway and their genetic variations in ischaemic stroke, "Journal of Clinical Pathology", v.71, N2, 2018, pp.141-147.
  5. Atshemyan S., Chavushyan A., Berberian N., Sahakyan A., Zakharyan R., Arakelyan A., Characterization of BRCA1/2 mutations in patients with family history of breast cancer in Armenia. "F1000Research", v.6, 2017, 29. doi:10.12688/f1000research.10434.1.
  6. Hovhannisyan L., Stepanyan A., Arakelyan A., Genetic variability of interleukin-1 beta as prospective factor from developing post-traumatic stress disorder, "Immunogenetics", 2017. doi: 10.1007/s00251-017-1016-4.
  7. Khoyetsyan A., Kacimi R., Tsakanova G., Boyajyan A, Arakelyan A, Yenari M.A., Activated complement protein C5a does not affect brain-derived endothelial cell viability and zonula occludens-1 levels following oxygen-glucose deprivation, "Brain Circulation", v.3, N1, 2017, p. 14-20.
  8. Malakyan M., Ayvazyan V., Manukyan G., Hovsepyan L., Arakelova E., Avetyan D., Ghazaryan H., Melkonyan A., Zakharyan R., Arakelyan A., Effects of Schiff base aromatic amino acid derivatives on antioxidant and immune system disturbances in a rat model of aflatoxin B1 induced experimental mycotoxicosis, "F1000Research", v.6, 2017, 1413. doi: 10.12688/f1000research.11756.1
  9. Tsakanova G., Arakelova E., Ayvazyan V., Ayvazyan A., Tatikyan S., Aroutiounian R., Dalyan Y., Haroutiunian S., Tsakanov V., Arakelyan A., Two-photon microscopy imaging of oxidative stress in human living erythrocytes, "Biomedical Optics Express", v.8, N12, 2017, p. 5834-5846.
  10. Tsakanova G., Stepanyan A., Nahapetyan K., Sim R.B., Arakelyan A., Boyajyan A., Serine proteases of the complement lectin pathway and their genetic variations in ischaemic stroke, "Journal of Clinical Pathology", 2017. doi:10.1136/jclinpath-2017-204403.

Patents received:

  1. Ayvazyan V., Boyadjyan A. A method of obtaining schizophrenia research model. // (2009), Patent # AM20090061, G09B 23/00.
  2. Avetisyan A., Alexanyan I., Durgaryan V., Lvov M., Boyajyan A., Hovsepyan L. Hydrochloric salts of 2-(1-chlor-1-bromoethyl)-4-methyl-2,3- dihydrofuro[3,2-c] quinoline derivants demonstrating antiarrythmic and antianginal activity. // (2008), Patent # AM20080211, C07D 491/00.
  3. Boyadjyan A., Khoyetsyan A., Arakelyan A. Method for schizophrenia diagnostics. // (2009), Patent # AM20090059, G01N 33/48.