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LABORATORY OF COMPUTATION MODELLING OF BIOLOGICAL PROCESSES
HEAD:
Lab members:
General information:
The Laboratory of computational modelling has been founded in 2007 on the basis of Laboratory of Organ specific Proteins.
Main priority of the Laboratory is to use modern methods of bioinformatics and computational biology for modelling and in silico
analysis of the processes of protein-protein, protein-ligand interactions and its regulation. For example, modelling of dynamic complex
formation between glycolytic enzymes bring better understanding of enzyme-enzyme interaction and its functional consequences and gave
a serious arguments in favour of metabollon formation and intermediate metabolite channelling. Investigation of tubulin-cytostatics
interaction had serious implications in terms of practical use in the case of genetically determined FMF treatment. Recent research
is focused on detailed in silico analysis of different domens and motives of pyrin-main protein, mutations of which are
responsible for FMF manifestation- with apoptosis factors. It revealed new ways to control development of FMF.
In the research process capacity of own computer cluster, work station and internationally available supercomputers has been used.
The Laboratory plays lead role in running of the Department of Bioinformatics, Bioengineering and Molecular Biology at Slavonic University.
Current research projects:
Currently the Laboratory of computation modelling of biological processes is implementing the project founded by National Academy of Sciences of the Republic of Armenia.
Selected Publications:
>> Full publications list of IMB