Since its inception the laboratory of cellular biology and virology engaged in the research of cytological status of the various
primary, secondary and transplantable cell lines during cultivation and the influence of various drugs and biologically active substances, as well
as viruses, on cells.
Subsequently, in the laboratory began to study the pathogenesis of viruses in vivo and in vitro conditions. The objects of interest
are picornaviruses (poliovirus, encephalomyocarditis and FMDV) and African swine fever virus (genotype 2).
For in vitro researches laboratory has a large bank of cultivating cell lines such as Hela, BHK, RD, Vero, Cos, etc.
In the last few years the laboratory has been actively working on the study of the African swine fever (ASF) virus which is distributes on the territory
of Armenia and neighboring Georgia. Clinical picture and pathology of blood and bone marrow in the ASF genotype 2 fully investigated.
A new direction in the activities of the laboratory are study of ASF virus genotype 2 complete genome, the phylogenetic definition of ASF virus (genotype 2),
as well as epigenetic changes in the genome.
Current research projects:
">To date, the laboratory was investigating:
- Molecular mechanisms of the pathogenesis of African swine fever (ASF) in the in vivo and in vitro conditions;
- Investigation of possible reservoirs of the African swine fever virus;
- Studying phylogeny of African swine fever virus genotype 2;
- Research of bioactive substances and chemical molecules for antiviral activity.
A study of lymphoid organs and serum proinflammatory cytokines in pigs infected with African swine fever virus genotype II. Zakaryan H,
Cholakyans V, Simonyan L, Misakyan A, Karalova E, Chavushyan A, Karalyan Z. Arch Virol. 2015 Jun;160(6):1407-14. doi: 10.1007/s00705-015-2401-7.
Epub 2015 Mar 24.
Evaluation of hemostaseological status of pigs experimentally infected with African swine fever virus. Zakaryan H, Karalova E, Voskanyan H,
Ter-Pogossyan Z, Nersisyan N, Hakobyan A, Saroyan D, Karalyan Z. Vet Microbiol. 2014 Nov 7;174(1-2):223-8. doi: 10.1016/j.vetmic.2014.08.029.
Epub 2014 Sep 6.
Interaction of Paramecium caudatum and Picornaviruses. Karalyan ZA, Voskanyan HE, Ramazyan NV, Zakaryan HS, Karalova EM. Indian J Virol.
2012 Dec;23(3):382-6. doi: 10.1007/s13337-012-0100-5. Epub 2012 Sep 18.
Pathology of porcine peripheral white blood cells during infection with African swine fever virus. Karalyan Z, Zakaryan H, Arzumanyan H,
Sargsyan K, Voskanyan H, Hakobyan L, Abroyan L, Avetisyan A, Karalova E. BMC Vet Res. 2012 Feb 28;8:18. doi: 10.1186/1746-6148-8-18.
Interferon status and white blood cells during infection with African swine fever virus in vivo. Karalyan Z, Zakaryan H, Sargsyan Kh,
Voskanyan H, Arzumanyan H, Avagyan H, Karalova E. Vet Immunol Immunopathol. 2012 Jan 15;145(1-2):551-5. doi: 10.1016/j.vetimm.2011.12.013.
Epub 2011 Dec 21.
Properties of cells with increased resistance to some picornaviruses. Karalyan ZA, Djaghatspanyan NG, Gasparyan MH, Hakobyan LA, Abroyan LO,
Ter-Pogossyan ZR, Zakaryan HS, Karalova EM. Microb Pathog. 2011 May;50(5):243-51. doi: 10.1016/j.micpath.2011.01.010. Epub 2011 Feb 3.